产品名称
EBF1 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1879
Human Swissprot No.
Q9UH73
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UH73
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13591
Mouse Swissprot No.
Q07802
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q07802/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116543
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63398/entry
特异性
This antibody detects endogenous levels of EBF1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Key pioneer transcription factor of B-cell specification and commitment . Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). ; (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells . In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency .
