产品名称
C8orf4 Rabbit Polyclonal Antibody
蛋白名称
Uncharacterized protein C8orf4 (Thyroid cancer protein 1) (TC-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56892
Human Swissprot No.
Q9NR00
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NR00
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69068
Mouse Swissprot No.
Q9D915
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D915/entry
特异性
This antibody detects endogenous levels of C8orf4 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347).
细胞定位
Cytoplasm . Nucleus, nucleolus . Nucleus speckle . Nucleus . Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). .
功能
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 . Enhances the proliferation of follicular dendritic cells . Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle . In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity . Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression . Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis . However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling .
