产品名称
ENSA Rabbit Polyclonal Antibody
蛋白名称
Alpha-endosulfine (ARPP-19e)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2029
Human Swissprot No.
O43768
Human Swissprot Link
https://www.uniprot.org/uniprot/O43768
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56205
Mouse Swissprot No.
P60840
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P60840/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60334
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P60841/entry
特异性
This antibody detects endogenous levels of ENSA at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.
功能
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
