产品名称
FAM158A Rabbit Polyclonal Antibody
基因名称
EMC9 C14orf122 FAM158A CGI-112
蛋白名称
ER membrane protein complex subunit 9 (Protein FAM158A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51016
Human Swissprot No.
Q9Y3B6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y3B6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85308
Mouse Swissprot No.
Q9DB76
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DB76/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=290224
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U1W7/entry
特异性
This antibody detects endogenous levels of FAM158A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
