产品名称
HSCB Rabbit Polyclonal Antibody
蛋白名称
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (DnaJ homolog subfamily C member 20) (Hsc20)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=150274
Human Swissprot No.
Q8IWL3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IWL3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100900
Mouse Swissprot No.
Q8K3A0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3A0/entry
特异性
This antibody detects endogenous levels of HSCB at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
细胞定位
[Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm .; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion .
功能
Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm . Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain . Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 . Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 . This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT .
