产品名称
3BP2 Rabbit Polyclonal Antibody
蛋白名称
SH3 domain-binding protein 2 (3BP-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P78314
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P78314/entry
Mouse Swissprot No.
Q06649
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q06649
免疫原
Synthesized peptide derived from human protein . at AA range: 210-290
特异性
3BP2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
组织表达
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
信号通路
Natural killer cell mediated cytotoxicity;
功能
disease:Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.,function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,tissue specificity:Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
