产品名称
FEM1A Rabbit Polyclonal Antibody
蛋白名称
Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55527
Human Swissprot No.
Q9BSK4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BSK4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=316131
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V890/entry
特异性
This antibody detects endogenous levels of FEM1A at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
细胞定位
Mitochondrion . Cytoplasm .
功能
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation . Promotes ubiquitination and degradation of SLBP . Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).
