产品名称
CTDSP2 Rabbit Polyclonal Antibody
基因名称
CTDSP2 NIF2 OS4 SCP2
蛋白名称
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10106
Human Swissprot No.
O14595
Human Swissprot Link
https://www.uniprot.org/uniprot/O14595
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52468
Mouse Swissprot No.
Q8BX07
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BX07/entry
特异性
This antibody detects endogenous levels of CTDSP2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
功能
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
