产品名称
ASTN2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23245
Human Swissprot No.
O75129
Human Swissprot Link
https://www.uniprot.org/uniprot/O75129
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56079
Mouse Swissprot No.
Q80Z10
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80Z10/entry
特异性
This antibody detects endogenous levels of ASTN2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Membrane ; Multi-pass membrane protein . Perikaryon . Cytoplasm, cell cortex . Early endosome . Late endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic vesicle . Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons. .
功能
Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).
