产品名称
3BP1 Rabbit Polyclonal Antibody
蛋白名称
SH3 domain-binding protein 1 (3BP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y3L3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y3L3/entry
Mouse Swissprot No.
P55194
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55194
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
3BP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.,sequence caution:Translated as Cys.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,
组织表达
Bladder,Colon,Melanoma,Pancreas,Uterus,
细胞定位
Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). .
功能
function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.,sequence caution:Translated as Cys.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
