产品名称
OTOP1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=133060
Human Swissprot No.
Q7RTM1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7RTM1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21906
Mouse Swissprot No.
Q80VM9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80VM9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305427
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q7M734/entry
特异性
This antibody detects endogenous levels of OTOP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Multi-pass membrane protein . Detected in the gelatinous membrane overlying the inner ear macular epithelium. .
功能
Proton-selective channel that specifically transports protons into cells . Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes . In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity).
