产品名称
Nesprin 4 Rabbit Polyclonal Antibody
蛋白名称
Nesprin-4 (Nuclear envelope spectrin repeat protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=163183
Human Swissprot No.
Q8N205
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N205
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233066
Mouse Swissprot No.
Q8CII8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CII8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911963
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5M844/entry
特异性
This antibody detects endogenous levels of Nesprin 4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus outer membrane ; Single-pass type IV membrane protein . Localization at the nucleus outer membrane requires the presence of SUN1. .
功能
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
