产品名称
MYEOV2 Rabbit Polyclonal Antibody
蛋白名称
Myeloma-overexpressed gene 2 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=150678
Human Swissprot No.
Q8WXC6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WXC6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66915
Mouse Swissprot No.
Q3U898
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U898/entry
特异性
This antibody detects endogenous levels of MYEOV2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
[Isoform 1]: Nucleus . Cytoplasm . Nucleus, nucleoplasm . Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. .; [Isoform 2]: Nucleus, nucleoplasm . Excluded from the nucleolus. .
功能
[Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. ; [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.
