产品名称
LMBRD1 Rabbit Polyclonal Antibody
基因名称
LMBRD1 C6orf209 NESI BM-021 CD001 MSTP044
蛋白名称
Probable lysosomal cobalamin transporter (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55788
Human Swissprot No.
Q9NUN5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NUN5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68421
Mouse Swissprot No.
Q8K0B2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0B2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246046
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AZ61/entry
特异性
This antibody detects endogenous levels of LMBRD1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 3 is expressed in liver.
细胞定位
Endoplasmic reticulum membrane . Lysosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle .
功能
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors . Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome . Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane . Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). ; [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).
