产品名称
LEPROT Rabbit Polyclonal Antibody
蛋白名称
Leptin receptor gene-related protein (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54741
Human Swissprot No.
O15243
Human Swissprot Link
https://www.uniprot.org/uniprot/O15243
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230514
Mouse Swissprot No.
O89013
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O89013/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56766
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLS8/entry
特异性
This antibody detects endogenous levels of LEPROT at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Golgi apparatus membrane ; Multi-pass membrane protein . Endosome membrane .
功能
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
