产品名称
GRHL1 Rabbit Polyclonal Antibody
基因名称
GRHL1 LBP32 MGR TFCP2L2
蛋白名称
Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29841
Human Swissprot No.
Q9NZI5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NZI5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=195733
Mouse Swissprot No.
Q921D9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q921D9/entry
特异性
This antibody detects endogenous levels of GRHL1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
功能
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' . Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). ; [Isoform 1]: Functions as transcription activator. ; [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
