产品名称
GCAP2 Rabbit Polyclonal Antibody
蛋白名称
Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2979
Human Swissprot No.
Q9UMX6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UMX6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107477
Mouse Swissprot No.
Q8VBV8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBV8/entry
特异性
This antibody detects endogenous levels of GCAP2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
In the retina, it is expressed in cone and rod photoreceptor cells.
细胞定位
Cell membrane ; Lipid-anchor . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .
功能
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
