产品名称
DELE1 Rabbit Polyclonal Antibody
蛋白名称
Death ligand signal enhancer
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9812
Human Swissprot No.
Q14154
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14154
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66839
Mouse Swissprot No.
Q9DCV6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCV6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=307480
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P60924/entry
特异性
This antibody detects endogenous levels of DELE1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
细胞定位
[DAP3-binding cell death enhancer 1]: Mitochondrion . Mitochondrion inner membrane . Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). .; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol . This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. .
功能
[DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress . In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR . Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation . ; [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI . It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR .
