产品名称
FAM62B Rabbit Polyclonal Antibody
基因名称
ESYT2 FAM62B KIAA1228
蛋白名称
Extended synaptotagmin-2 (E-Syt2) (Chr2Syt)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57488
Human Swissprot No.
A0FGR8
Human Swissprot Link
https://www.uniprot.org/uniprot/A0FGR8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52635
Mouse Swissprot No.
Q3TZZ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TZZ7/entry
特异性
This antibody detects endogenous levels of FAM62B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with high level in cerebellum.
细胞定位
Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437). .
功能
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) .
