产品名称
SH2D3 Rabbit Polyclonal Antibody
基因名称
SH2D3C NSP3 UNQ272/PRO309/PRO34088
蛋白名称
SH2 domain-containing protein 3C (Novel SH2-containing protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N5H7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N5H7/entry
Mouse Swissprot No.
Q9QZS8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZS8
免疫原
Synthesized peptide derived from part region of human protein
特异性
SH2D3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
组织表达
[Isoform 1]: Ubiquitously expressed.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, ruffle membrane . Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). .; [Isoform 1]: Cell membrane ; Peripheral membrane protein .
功能
function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the membrane when EGF-stimulated. Found at ruffling membranes.,subunit:Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
