产品名称
VASH2 Rabbit Polyclonal Antibody
蛋白名称
Vasohibin-2 (Vasohibin-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79805
Human Swissprot No.
Q86V25
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86V25
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=226841
Mouse Swissprot No.
Q8C5G2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C5G2/entry
特异性
This antibody detects endogenous levels of VASH2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Secreted . Cytoplasm, cytoskeleton . Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911). .
功能
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function . Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning . Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis . Plays a role in axon formation .
