产品名称
DTD1 Rabbit Polyclonal Antibody
蛋白名称
D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (Histidyl-tRNA synthase-related)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92675
Human Swissprot No.
Q8TEA8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TEA8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66044
Mouse Swissprot No.
Q9DD18
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DD18/entry
特异性
This antibody detects endogenous levels of DTD1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
细胞定位
Nucleus . Cytoplasm . Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
功能
Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes . ; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
