产品名称
TCP11 Rabbit Polyclonal Antibody
蛋白名称
T-complex protein 11 homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6954
Human Swissprot No.
Q8WWU5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WWU5
Mouse Swissprot No.
Q01755
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q01755/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309641
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XI00/entry
特异性
This antibody detects endogenous levels of TCP11 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) (PubMed:21597245). Testis-specific (PubMed:11756566). Isoform 1, isoform 2 and isoform 3 are expressed in sperm (PubMed:21597245).
细胞定位
Membrane ; Single-pass membrane protein . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. .
功能
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
