产品名称
FBP17 Rabbit Polyclonal Antibody
基因名称
FNBP1 FBP17 KIAA0554
蛋白名称
Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23048
Human Swissprot No.
Q96RU3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96RU3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14269
Mouse Swissprot No.
Q80TY0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TY0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=192348
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R511/entry
特异性
This antibody detects endogenous levels of FBP17 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
功能
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
