产品名称
PILRA Rabbit Polyclonal Antibody
蛋白名称
Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29992
Human Swissprot No.
Q9UKJ1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UKJ1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231805
Mouse Swissprot No.
Q2YFS3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q2YFS3/entry
特异性
This antibody detects endogenous levels of PILRA at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .
功能
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. ; (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
