产品名称
NGEF Rabbit Polyclonal Antibody
蛋白名称
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25791
Human Swissprot No.
Q8N5V2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N5V2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53972
Mouse Swissprot No.
Q8CHT1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHT1/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BKC9/entry
特异性
This antibody detects endogenous levels of NGEF at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
细胞定位
Cytoplasm . Membrane . Cell projection, growth cone . Associated with membranes. Localizes to axonal growth cones (By similarity). .
功能
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
