产品名称
CIAO1 Rabbit Polyclonal Antibody
蛋白名称
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9391
Human Swissprot No.
O76071
Human Swissprot Link
https://www.uniprot.org/uniprot/O76071
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26371
Mouse Swissprot No.
Q99KN2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99KN2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29231
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5M7T1/entry
特异性
This antibody detects endogenous levels of CIAO1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 . Seems to specifically modulate the transactivation activity of WT1 . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation .
