产品名称
NUDT3/4/10/11 Rabbit Polyclonal Antibody
蛋白名称
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11165
Human Swissprot No.
O95989
Human Swissprot Link
https://www.uniprot.org/uniprot/O95989
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56409
Mouse Swissprot No.
Q9JI46
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JI46/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294292
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q566C7/entry
特异性
This antibody detects endogenous levels of NUDT3/4/10/11 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
功能
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . InsP6 (inositol hexakisphosphate) is not a substrate . Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates . The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility .
