产品名称
CAMK1D Rabbit Polyclonal Antibody
蛋白名称
Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57118
Human Swissprot No.
Q8IU85
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IU85
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=227541
Mouse Swissprot No.
Q8BW96
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BW96/entry
特异性
This antibody detects endogenous levels of CAMK1D at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
功能
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
