产品名称
GCOM1 Rabbit Polyclonal Antibody
蛋白名称
Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100820829
Human Swissprot No.
P0CAP1
Human Swissprot Link
https://www.uniprot.org/uniprot/P0CAP1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=102371
Mouse Swissprot No.
Q3UIJ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UIJ9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363091
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EB94/entry
特异性
This antibody detects endogenous levels of GCOM1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. Expressed in arrector pili muscle (at protein level) (PubMed:29034528).
细胞定位
Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, myofibril, sarcomere, I band . Cytoplasm, myofibril, sarcomere, Z line . Cell junction . Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. .
功能
Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
