产品名称
MMADHC Rabbit Polyclonal Antibody
基因名称
MMADHC C2orf25 CL25022 HSPC161 My011
蛋白名称
Methylmalonic aciduria and homocystinuria type D protein, mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27249
Human Swissprot No.
Q9H3L0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H3L0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109129
Mouse Swissprot No.
Q99LS1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99LS1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362134
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYQ6/entry
特异性
This antibody detects endogenous levels of MMADHC at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed at high levels.
细胞定位
Cytoplasm . Mitochondrion .
功能
Involved in cobalamin metabolism and trafficking . Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) . Promotes oxidation of cob(II)alamin bound to MMACHC . The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine .
