产品名称
TBC1D17 Rabbit Polyclonal Antibody
蛋白名称
TBC1 domain family member 17
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79735
Human Swissprot No.
Q9HA65
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HA65
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233204
Mouse Swissprot No.
Q8BYH7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYH7/entry
特异性
This antibody detects endogenous levels of TBC1D17 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic vesicle, autophagosome .
功能
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.
