产品名称
CUEDC2 Rabbit Polyclonal Antibody
基因名称
CUEDC2 C10orf66 HOYS6
蛋白名称
CUE domain-containing protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79004
Human Swissprot No.
Q9H467
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H467
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67116
Mouse Swissprot No.
Q9CXX9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CXX9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294009
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A1L131/entry
特异性
This antibody detects endogenous levels of CUEDC2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
细胞定位
Cytoplasm . Nucleus .
功能
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
