产品名称
PCSK4 Rabbit Polyclonal Antibody
基因名称
PCSK4 PC4 UNQ2757/PRO6496
蛋白名称
Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54760
Human Swissprot No.
Q6UW60
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6UW60
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18551
Mouse Swissprot No.
P29121
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P29121/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171085
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q78EH2/entry
特异性
This antibody detects endogenous levels of PCSK4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, acrosome membrane .
功能
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 . May also participate in folliculogenesis in the ovaries (By similarity).
