产品名称
MAEL Rabbit Polyclonal Antibody
蛋白名称
Protein maelstrom homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84944
Human Swissprot No.
Q96JY0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96JY0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98558
Mouse Swissprot No.
Q8BVN9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVN9/entry
特异性
This antibody detects endogenous levels of MAEL at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
细胞定位
Cytoplasm . Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). .
功能
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
