产品名称
FCHO1 Rabbit Polyclonal Antibody
蛋白名称
FCH domain only protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23149
Human Swissprot No.
O14526
Human Swissprot Link
https://www.uniprot.org/uniprot/O14526
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74015
Mouse Swissprot No.
Q8K285
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K285/entry
特异性
This antibody detects endogenous levels of FCHO1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in lymphoid cells.
细胞定位
Membrane, clathrin-coated pit ; Peripheral membrane protein ; Cytoplasmic side . Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
功能
Functions in an early step of clathrin-mediated endocytosis . Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation . Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation .
