产品名称
SH2D3 Rabbit Polyclonal Antibody
基因名称
SH2D3C NSP3 UNQ272/PRO309/PRO34088
蛋白名称
SH2 domain-containing protein 3C (Novel SH2-containing protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N5H7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N5H7/entry
Mouse Swissprot No.
Q9QZS8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZS8
免疫原
Synthesized peptide derived from part region of human protein
特异性
SH2D3 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
组织表达
[Isoform 1]: Ubiquitously expressed.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, ruffle membrane . Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). .; [Isoform 1]: Cell membrane ; Peripheral membrane protein .
功能
function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the membrane when EGF-stimulated. Found at ruffling membranes.,subunit:Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
