产品名称
MIER1 Rabbit Polyclonal Antibody
蛋白名称
Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57708
Human Swissprot No.
Q8N108
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N108
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71148
Mouse Swissprot No.
Q5UAK0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5UAK0/entry
特异性
This antibody detects endogenous levels of MIER1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
细胞定位
[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.
功能
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
