产品名称
PP4R1 Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein phosphatase 4 regulatory subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8TF05
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TF05/entry
Mouse Swissprot No.
Q8K2V1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K2V1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VI02
免疫原
Synthesized peptide derived from part region of human protein
特异性
PP4R1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
组织表达
Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.
细胞定位
protein phosphatase 4 complex,
功能
function:Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.,similarity:Contains 14 HEAT repeats.,subunit:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3.,tissue specificity:Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
