产品名称
CHORDC1 Rabbit Polyclonal Antibody
蛋白名称
Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26973
Human Swissprot No.
Q9UHD1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UHD1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66917
Mouse Swissprot No.
Q9D1P4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D1P4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315447
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D4A4T9/entry
特异性
This antibody detects endogenous levels of CHORDC1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Underexpressed in many breast and lung cancers.
功能
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 . Proposed to act as co-chaperone for HSP90 . May play a role in the regulation of NOD1 via a HSP90 chaperone complex . In vitro, has intrinsic chaperone activity . This function may be achieved by inhibiting association of ROCK2 with NPM1 . Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling . Involved in stress response . Prevents tumorigenesis .
