产品名称
PP2BC Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P48454
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P48454/entry
Mouse Swissprot No.
P48455
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48455
免疫原
Synthesized peptide derived from part region of human protein
特异性
PP2BC Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
细胞定位
Mitochondrion . Localizes in the mitochondria in a SPATA33-dependent manner. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Oocyte meiosis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;WNT;WNT-T CELLAxon guidance;VEGF;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_Cell_Antigen;Long-term potentiation;Alzheime
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.,tissue specificity:Testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
