产品名称
SULT2B1 Rabbit Polyclonal Antibody
蛋白名称
Sulfotransferase family cytosolic 2B member 1 (ST2B1) (Sulfotransferase 2B1) (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6820
Human Swissprot No.
O00204
Human Swissprot Link
https://www.uniprot.org/uniprot/O00204
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54200
Mouse Swissprot No.
O35400
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35400/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292915
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q29YR5/entry
特异性
This antibody detects endogenous levels of SULT2B1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594).
细胞定位
Cytoplasm, cytosol . Microsome . Nucleus . Phosphorylation of Ser-348 is required for translocation to the nucleus. .
功能
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol . Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) . Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA . Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation . ; [Isoform 2]: Sulfonates pregnenolone but not cholesterol.
