产品名称
PRR14 Rabbit Polyclonal Antibody
蛋白名称
Proline-rich protein 14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78994
Human Swissprot No.
Q9BWN1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BWN1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233895
Mouse Swissprot No.
Q7TPN9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TPN9/entry
特异性
This antibody detects endogenous levels of PRR14 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Chromosome . Nucleus . Nucleus lamina . Nucleus, nucleoplasm . During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. .
功能
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha . Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit . Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha . Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 .
