产品名称
KCNIP4 Rabbit Polyclonal Antibody
蛋白名称
Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80333
Human Swissprot No.
Q6PIL6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6PIL6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80334
Mouse Swissprot No.
Q6PHZ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PHZ8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=259243
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99MG9/entry
特异性
This antibody detects endogenous levels of KCNIP4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in brain.
细胞定位
Cell membrane ; Peripheral membrane protein . Cytoplasm .; [Isoform 4]: Endoplasmic reticulum .
功能
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner . Modulates KCND3/Kv4.3 currents . Isoform 4 does not increase KCND2 expression at the cell membrane . Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
