产品名称
Claudin 16 Rabbit Polyclonal Antibody
蛋白名称
Claudin-16 (Paracellin-1) (PCLN-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10686
Human Swissprot No.
Q9Y5I7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y5I7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114141
Mouse Swissprot No.
Q925N4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q925N4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155268
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Y55/entry
特异性
This antibody detects endogenous levels of Claudin 16 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Kidney-specific, including the thick ascending limb of Henle (TAL).
细胞定位
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
功能
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
