产品名称
Advillin Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10677
Human Swissprot No.
O75366
Human Swissprot Link
https://www.uniprot.org/uniprot/O75366
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11567
Mouse Swissprot No.
O88398
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88398/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WU06/entry
特异性
This antibody detects endogenous levels of Advillin at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus (PubMed:12034507). Expressed in podocytes (at protein level) (PubMed:29058690).
细胞定位
Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell junction, focal adhesion . Cell projection, neuron projection . Cell projection, axon . In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. .
功能
Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling . May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly .
