产品名称
GUK1 Rabbit Polyclonal Antibody
蛋白名称
Guanylate kinase (EC 2.7.4.8) (GMP kinase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2987
Human Swissprot No.
Q16774
Human Swissprot Link
https://www.uniprot.org/uniprot/Q16774
Mouse Swissprot No.
Q64520
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64520/entry
特异性
This antibody detects endogenous levels of GUK1 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Photoreceptor inner segment . Cytoplasm, cytosol . Colocalizes with RD3 in photoreceptor inner segments and to a lesser extent in the outer plexiform layer. .
功能
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) . Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors . In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine .
