产品名称
dGK Rabbit Polyclonal Antibody
蛋白名称
Deoxyguanosine kinase, mitochondrial (dGK) (EC 2.7.1.113)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1716
Human Swissprot No.
Q16854
Human Swissprot Link
https://www.uniprot.org/uniprot/Q16854
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27369
Mouse Swissprot No.
Q9QX60
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QX60/entry
特异性
This antibody detects endogenous levels of dGK at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
功能
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine . In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents.
