产品名称
FAN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8439
Human Swissprot No.
Q92636
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92636/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18201
Mouse Swissprot No.
O35242
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35242
免疫原
Synthesized peptide derived from human FAN AA range: 147-197
特异性
This antibody detects endogenous levels of FAN at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009],
细胞定位
cytoplasm,cytosol,endomembrane system,extrinsic component of membrane,
功能
function:Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.,similarity:Contains 1 BEACH domain.,similarity:Contains 1 GRAM domain.,similarity:Contains 6 WD repeats.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
