产品名称
TMEM106A Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 106A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113277
Human Swissprot No.
Q96A25
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96A25
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=217203
Mouse Swissprot No.
Q8VC04
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VC04/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287722
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BK83/entry
特异性
This antibody detects endogenous levels of TMEM106A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in renal cells (at protein level) (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879).
细胞定位
Cell membrane ; Single-pass membrane protein .
功能
Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration .
